[Enhancing the dissolution rate of felodipine by mechanical activation]

This research aimed to study the effect of mechanical activation [Slugging and Milling "SM"] on the physiochemical properties of the Felodipine with hydrophilic polymer was studied. Two types of PhysicalMixtures [PM] was prepared: The first one was physical mixture of Felodipine with poly ethylene glycol [PEG6000] and / or surfactant which is poloxamer [POL], and the second one was physical mixture of Felodipine with poly vinyl pyrolidine [PVP] and / or surfactant which is poloxamer. Then slugging and milling [SM] was made for each mixture. To know the effect of SM on the physiochemical properties of the previous prepared mixture, a comparison between each mixture before and after SM was made, by using differential scanning calorimetry [DSC], Fourier Transmission Infrared [FTIR] and X-ray diffractometry. The effect of [SM] on the mechanochemistry of each material was studied by comparison the DSC scan for each material alone before and after SM. Finally the physical interaction between polymer [PEG or PVP] and surfactant [POL] was studied. The result of DSC showed that is a physical interaction between polymer and Felodipine in case of SM, but this interaction were absent in case of the physical mixture. The result of DSC also showed the effect of SM on the mechanochemistry of the used material. The result of FTIR showed a hydrophilic interaction between Felodipine and polymer in case of SM and also showed a significant interaction between polymer [PVP] and surfactant [POL]. Finally the result of X-ray showed that Felodipine remains in his crystal form after SM

Toxoplasma gondii infection in pregnant women with previous adverse pregnancy outcome

Adverse pregnancy outcome include two or more consecutive spontaneous abortions, intrauterine foetal death, intrauterine growth retardation, low birth weight, stillbirths, early neonatal death and/or congenital anomalies. Maternal infections and infestations play a critical role in adverse pregnancy outcome. In Libya, scare data exist on the roles of Toxoplasma gondii [T.Gondii] in the etiology of adverse pregnancy outcome. The aim of this study was to evaluate the seroprevalence of T. gondii in relation to previous adverse pregnancy outcome in pregnant women. We also aimed to find out the possible risk factors of acquiring this infection in Libyan women at Benghazi region. We included 143 pregnant women with adverse pregnancy outcome who attended Gynecology and Obstetric Department in Jamhoriya Teaching Hospital over a period of six months to estimate seroprevalences of IgM and IgG antibodies to Toxoplasma gondii. Serum samples were collected and assayed using quantitative ELISA technique. Out of 143 serum sample, 64 [44.8%] were positive for Toxoplasma. IgM seropositivities to Toxoplasma were 8.4%. All of those with high IgG and IgM positive cases gave a positive history of habitual abortion. Further remarks were obtained and will be presented and stressed

Macro- and micromorphology of the leaves, stems and flowers of Chrysanthemum carinatum L.

The genus Chrysanthemum L. is sometimes called Ismelia, it comprises about 150 species native to tropical and temperate North and South America. Chrysanthemum carinatum L. is known as Painted daisy, German flag and Tricolor Chrysanthemum. Some species of genus Chrysanthemum are used medicinally to cure influenza symptoms, liver and menstrual disorders and have anti-inflammatory and antispasmodic effects